报告人： Professor Ikuro Abe (日本The University of Tokyo)
时 间 ： 4月4日 (星期三) 15:00-17:00
地 点： 药学院225室
主持人： 戚建华教授，杜艺岭 研究员
Research and Professional Experience :
1989/7-1991/9 Boursier du Gouvernement Français and Boursier Maxwell de l'Academie des Sciences (CNRS). Institut de Chimie des Substances Naturells (CNRS), and Ecole Nationale Supérieure de Chimie de Mulhouse (Profs. Guy Ourisson and Michel Rohmer)
1991/10-1996/7 Research Assistant Professor, Department of Chemistry, State University of New York at Stony Brook (Prof. Glenn D. Prestwich)
1996/8-1998/3 Research Assistant Professor, Department of Medicinal Chemistry, The University of Utah (Prof. Glenn D. Prestwich)
1998/4-2009/4 Associate Professor, School of Pharmaceutical Sciences, University of Shizuoka
2009/5-present Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
2014/6 Visiting Professor, The University of British Columbia, Canada
Representative Publications:
1.Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis. Nakashima, Y., Mori, T., Nakamura, H., Awakawa, T., Hoshino, S., Senda, M., Senda, T., Abe, I. Nature Commun., 9, DOI: 10.1038/s41467-017-02371-w (2018)
2.Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis. Mori, T., Iwabuchi, T., Hoshino, S., Wang, H., Matsuda, Y., Abe, I. Nature Chem. Biol., 13, 1066-1073 (2017)
3.Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis. Lv, J.-M., Hu, D., Gao, H., Kushiro, T., Awakawa, T., Chen, G.-D., Wang, C.-X., Abe, I., Yao, X.-S. Nature Commun., 8, DOI: 10.1038/s41467-017-01813-9 (2017)
4.Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases. Mori, T., Zhang, L., Awakawa, T., Hoshino, S., Okada, M., Morita, H., Abe, I. Nature Commun., 7, DOI: 10.1038/ncomms10849 (2016)
5.An environmental bacterial taxon with a large and distinct metabolic repertoire. Wilson, M. C., Mori, T., Rückert, C., Uria, A. R., Helf, M. J., Takada, K., Gernert, C., Steffens, U. A. E., Heycke, N., Schmitt, S., Rinke, C., Helfrich, E. J. N., Brachmann, A. O., Gurgui, C., Wakimoto. T., Kracht, M., Crüsemann, M., Hentschel, U., Abe, I., Matsunaga, S., Kalinowski, J., Takeyama, H., Piel, J. Nature, 506, 58-62 (2014)
主办：浙江大学药学院
网址链接：http://www.cps.zju.edu.cn/index.php?c=index&a=detail&id=22657&web=chinese
